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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Pozzolans

Pozzolans are siliceous or aluminous materials blended with Portland cement. They interact with the calcium hydroxide produced during the hydration of Portland cement and contribute to improved strength and durability of concrete. The pozzolanic activity, a measure of a pozzolan's effectiveness, is typically assessed using the strength activity index, as defined in ASTM C 618-93, which calculates the ratio of the compressive strength of cement mixtures with and without pozzolan.
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A weir is a hydraulic structure designed to partially obstruct an open channel, enabling precise control and measurement of water flow. By forcing water to flow over or through it, a weir allows for accurate determination of discharge rates, making it an essential tool in water resource management. These structures are extensively used in regulating river flows, irrigation systems, and flood control channels.Types of Weirs and Their FeaturesWeirs are categorized primarily into sharp-crested and...
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Ellipses

An ellipse is formed when a right circular cone is intersected by an inclined plane that does not cut through its base. This intersection yields a closed, symmetric curve characterized by distinctive geometric properties. Most notably, an ellipse is defined as the collection of all points in a plane for which the combined distances to two fixed points—called the foci—remain constant.The ellipse features two principal axes: the major and the minor axes. The major axis is the longest diameter,...
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The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
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Related Experiment Video

Updated: May 11, 2026

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
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Q&A with Ilaria Elia.

Ilaria Elia

    Cell Reports
    |November 30, 2024
    PubMed
    Summary

    This research explores the metabolic interactions between cancer cells and immune cells in the tumor microenvironment. Understanding these dynamics is crucial for developing new cancer therapies.

    Area of Science:

    • Oncology
    • Cancer Metabolism
    • Immunology

    Background:

    • Investigating the metabolic interplay between neoplastic cells and immune cells within the tumor microenvironment.
    • Focus on how cellular metabolism influences the tumor ecosystem and anti-cancer immunity.

    Discussion:

    • Exploring the complex metabolic crosstalk that supports tumor growth and immune evasion.
    • Highlighting the role of nutrient competition and metabolic byproducts in shaping the tumor microenvironment.

    Key Insights:

    • Metabolic interactions are a critical determinant of cancer progression and immune response.
    • Targeting cancer cell metabolism can potentially enhance anti-tumor immunity.

    Outlook:

    • Future research directions in cancer metabolism and immuno-oncology.
    Keywords:
    CP: CancerCP: Metabolism

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  • Potential for novel therapeutic strategies by modulating metabolic pathways in cancer and immune cells.