Impacts of food additives on gut microbiota and host health

The rapidly expanding food industry necessitates the use of food additives to achieve specific purposes. However, this raises new concerns in food safety due to the reported negative impacts of food additives on gut microbiota and host health, particularly in the context of continuous worldwide urbanization. This review summarizes the existing studies on the effects of different types of commonly used food additives on gut microbiota alteration, intestinal barrier disruption, metabolism disorder, and neurobehavior changes. These food additives, including emulsifiers, low-calorie sweeteners, inorganic nanoparticles, and preservatives, have been found to exert multifaceted impacts, primarily adverse effects, highlighting the potential risks associated with food additive exposure in various chronic diseases. Further research is warranted to elucidate the specific mechanisms, determine the relevance of these findings to humans, and clarify the suitability of certain food additives for vulnerable populations. It is crucial to note that natural food additives are not inherently superior to synthetic ones in terms of safety. Rigorous evaluation is still warranted before their widespread application in the food industry. Additionally, the potential synergistic effects of commonly used food additives combination in specific food categories on gut microbiota and host metabolism should be investigated to understand their relevance in real-world scenarios.