JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

The prognostic value of tumor microenvironment in endometrioid type endometrial cancer: Effect of CD44 on oncologic outcome

  • 0Department of Gynecologic Oncology, Ankara City Hospital, Ankara, Turkey.
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics +

|

November 30, 2024

|

November 30, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

CD44 is a key prognostic marker in endometrioid endometrial cancer (EEC), correlating with survival. While other markers like TNF-α and IL-1 show associations with tumor characteristics, CD44 is the strongest predictor of patient outcomes in EEC.

Area Of Science

  • Oncology
  • Molecular Pathology

Background

  • Endometrioid endometrial cancer (EEC) is the most common type of uterine malignancy.
  • Identifying reliable prognostic markers is crucial for improving patient management and outcomes.

Purpose Of The Study

  • To evaluate the expression of CD44, CD47, interleukin-1 (IL-1), and tumor necrosis factor alpha (TNF-α) in EEC.
  • To determine the correlation of these markers with clinicopathologic parameters and patient survival.

Main Methods

  • Immunohistochemistry (IHS) was employed to assess the expression levels of CD44, CD47, IL-1, and TNF-α in 53 EEC tissue samples.
  • Immunostaining intensity was categorized from negative to strongly positive.
  • Prognostic value was analyzed against clinicopathologic features, including survival data.

Main Results

  • High positivity rates were observed for CD44 (81%) and CD47 (81%) in EEC tissues.
  • Strong CD44 expression correlated with improved survival, reduced recurrence, and was linked to endocervical invasion and tumor stage.
  • Slightly positive CD47 was associated with increased lymph node metastasis; strong TNF-α with high-grade EEC; and slight IL-1 with endocervical invasion. No survival correlation was found for CD47, IL-1, or TNF-α.

Conclusions

  • CD44 expression emerged as a significant independent prognostic marker for overall survival and recurrence in EEC.
  • TNF-α and IL-1 may play indirect roles in EEC progression, correlating with tumor grade and invasion.
  • CD44 holds potential as a valuable biomarker for predicting prognosis in endometrioid endometrial cancer.

Keywords: