Related Experiment Video
Updated: Jun 6, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Association Between Air Pollution and Osteoporosis with High-Risk Populations: A Narrative Review
Hyejung Lee1, Yejin Kim1, Sojin Ahn2
1Department of Information Convergence Engineering, Pusan National University, Yangsan, South Korea.
Purpose Of Review:
Air pollution has been raised as a novel risk factor for osteoporosis, which impose a huge burden on both individuals and society. Thus, summarizing and discussing previous results on the association between ambient air pollution and osteoporosis can be informative in synthesizing the current evidence and improving relevant action plans.
Recent Findings:
Recent studies reported that long-term exposure to ambient air pollution is associated with an increased risk of osteoporosis and related outcomes; however, the studied populations, air pollutants, areas, and results on high-risk populations are heterogeneous. Among air pollutants, long-term exposure to PM2.5 showed an association with osteoporosis or osteoporosis-related fracture in general. Recent scientific evidence indicates that ambient air pollution is a potential risk factor for osteoporosis and related outcomes. Further research is warranted on how air pollution impacts these outcomes including for high-risk populations with consistent effect modifiers, and analytic methodologies.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Bone Remodeling
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Chronic Obstructive Pulmonary Disease-I: Introduction

