Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.1K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.1K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.8K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
3.8K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

1.2K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
1.2K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Production of Formed Elements01:34

Production of Formed Elements

1.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic insights into somatic mutations from occupational exposure to low-dose ionizing radiation.

Scandinavian journal of work, environment & health·2026
Same author

Optimal exercise strategies to improve HDL-C in metabolic syndrome: A systematic review with pairwise, network, and dose-response meta-analysis.

Journal of sport and health science·2026
Same author

Janus-like WC-Co Heterostructures Enable Orbital-Level Modulation for Durable Seawater Zinc-Air Batteries.

ACS nano·2026
Same author

Integrative Pan-Cancer Mapping of Proteasome Dependency Prioritizes PSMB5 and PSMB6 as Context-Dependent Vulnerability Biomarkers Linked to Immune Context.

Molecules (Basel, Switzerland)·2026
Same author

Artificial intelligence in 3D bioprinting and biofabrication: a validation-stringency assessment.

Biofabrication·2026
Same author

Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease.

Angiogenesis·2026

Related Experiment Video

Updated: Jun 6, 2025

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.7K

ERRα is dispensable for hematopoietic stem cell function in the bone marrow.

Hee Eun Bae1, Ninib Baryawno2, Byoung Soo Kim3

  • 1Department of Convergence Medicine, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea.

Biochemical and Biophysical Research Communications
|November 30, 2024
PubMed
Summary

Estrogen-related receptor α (ERRα) does not impact hematopoietic stem cell (HSC) function or populations in the bone marrow. Ablating ERRα in mice showed no significant changes in blood cell production or HSC maintenance under stress.

Keywords:
Bone marrow nicheERRαHematopoietic stem cells

More Related Videos

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

7.9K
Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
11:40

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

Published on: October 20, 2014

8.5K

Related Experiment Videos

Last Updated: Jun 6, 2025

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.7K
Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

7.9K
Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
11:40

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

Published on: October 20, 2014

8.5K

Area of Science:

  • Hematology
  • Molecular Biology
  • Cell Biology

Background:

  • Hematopoietic stem cells (HSCs) are crucial for blood cell production and reside in the bone marrow (BM).
  • Estrogen-related receptor α (ERRα) is involved in metabolic regulation and linked to acute myeloid leukemia (AML) development.
  • The specific role of ERRα in HSC regulation and function is largely unknown.

Purpose of the Study:

  • To investigate the role of Estrogen-related receptor α (ERRα) in the regulation and maintenance of hematopoietic stem and progenitor cells (HSPCs).
  • To determine if ERRα is essential for HSC function under normal conditions and stress, such as bone marrow transplantation.

Main Methods:

  • Utilized knockout (KO) and conditional KO (cKO) mouse models lacking Errα.
  • Employed flow cytometric analysis to assess HSPC populations.
  • Conducted bone marrow (BM) transplantation assays to evaluate HSC function and reconstitution capacity.

Main Results:

  • Ablation of Errα in the bone marrow did not alter the production of mature blood cells or lineage distribution.
  • Frequencies of hematopoietic stem and progenitor cell (HSPC) populations remained similar to control groups.
  • Hematopoietic stem cell (HSC) function was not perturbed by Errα ablation, even under the stress of transplantation.

Conclusions:

  • Estrogen-related receptor α (ERRα) is not essential for the maintenance of hematopoietic stem cell (HSC) populations within the bone marrow.
  • ERRα does not play a critical role in controlling HSC characteristics and functions.
  • These findings clarify the role of ERRα, suggesting it is not a key regulator of normal HSC biology.