Recoverability of Bladder Function in Patients With Defunctionalized Bladder and Live-Donor Kidney Transplantation

Area of Science:

• Urology
• Nephrology
• Transplantation Medicine

Background:

• Uremia significantly impacts bladder function, leading to defunctionalization in end-stage renal disease (ESRD) patients.
• Assessing bladder recoverability is crucial for patients undergoing live-donor kidney transplantation.

Purpose of the Study:

• To evaluate the functional recovery of defunctionalized bladders in patients with uremia after live-donor kidney transplantation.
• To determine the urodynamic changes in the bladder before and after kidney transplantation.

Main Methods:

• Invasive urodynamics were performed on 32 patients with stage 5 ESRD before and 6 months after live-donor kidney transplantation.
• Defunctionalized bladder was defined as anuria or oliguria for at least 6 months.
• Statistical analysis included t-tests, ANOVA, and Pearson's Correlation coefficient.

Main Results:

• Significant improvements were observed in bladder capacity (253 to 389 mL), compliance (26 to 33), and filling pressure (decreased by 12 cm H2O).
• Maximum flow rate (Qmax) increased from 13 to 16 mL/s, and detrusor overactivity decreased in prevalence and amplitude.
• Bladder capacity, compliance, and filling pressures showed statistically significant improvements post-transplantation (P < .007).

Conclusions:

• Urodynamic parameters of defunctionalized bladders significantly improve after live-donor kidney transplantation.
• Defunctionalized bladders can be cautiously utilized for live-donor transplants, offering favorable functional outcomes.