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Obesity with low bone mineral density is a risk for cerebral small-vessel disease in older adults: The Bunkyo Health Study

  • 0Department of Metabolism & Endocrinology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Obesity Research & Clinical Practice +

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November 30, 2024

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November 30, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The coexistence of obesity and low bone mineral density (BMD) in older adults significantly increases the risk of cerebral small-vessel disease (cSVD). This combined condition, present in about 8% of the elderly, is an independent risk factor for cSVD.

Area Of Science

  • Gerontology
  • Neurology
  • Metabolic Disorders

Background

  • Cerebral small-vessel disease (cSVD) is a major risk factor for stroke and dementia.
  • Obesity and low bone mineral density (BMD) are independently linked to cSVD.
  • The coexistence of obesity and low BMD, though often inversely related, may elevate cSVD risk.

Purpose Of The Study

  • To determine the prevalence of coexisting obesity and low BMD in older adults.
  • To investigate the association between this coexistence and the prevalence of cSVD.

Main Methods

  • Cross-sectional study using baseline data from the Bunkyo Health Study (n=1531, aged 65-84).
  • Participants underwent dual-energy X-ray absorptiometry and brain MRI.
  • cSVD defined by imaging markers; obesity by BMI; low BMD by osteoporosis (women) or osteopenia/osteoporosis (men).

Main Results

  • The prevalence of obesity with low BMD was approximately 8% in both women and men.
  • Overall cSVD prevalence was 23.2%.
  • Coexisting obesity and low BMD showed significantly increased odds ratios for cSVD (OR=2.33 in women, OR=2.80 in men) compared to the reference group.

Conclusions

  • The coexistence of obesity and low BMD is present in about 8% of older adults.
  • This combined condition is independently associated with a higher prevalence of cerebral small-vessel disease.

Keywords:

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