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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Altered...
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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Related Experiment Video

Updated: Jun 6, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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Gut Microbiota and Metabolite Profiles Associated With Functional Constipation Severity.

Jiwei Wang1, Jixin He1, Dandan Liu1

  • 1Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Microbiology and Immunology
|December 1, 2024
PubMed
Summary

Severe functional constipation (FC) is linked to higher anxiety and distinct gut microbiome changes, including increased Bacteroidota. Specific metabolic pathways and reduced butyric acid may also play a role in FC severity.

Keywords:
anxietybutyric acidfunctional constipationintestinal florametaboliteshort‐chain fatty acid

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Area of Science:

  • Gastroenterology
  • Microbiome Research
  • Metabolomics

Background:

  • Functional constipation (FC) significantly impacts patient quality of life.
  • FC is associated with an increased risk of intestinal tumors.
  • Understanding gut microbiome and metabolite alterations in FC is crucial.

Purpose of the Study:

  • To investigate changes in intestinal flora and metabolites across different severities of functional constipation.
  • To identify potential diagnostic and therapeutic targets for FC.

Main Methods:

  • Cross-sectional study design.
  • 16S rRNA sequencing for intestinal flora analysis.
  • Metabolomics analysis, including short-chain fatty acid profiling.

Main Results:

  • Severe FC patients exhibited higher clinical and anxiety scores.
  • Increased microbial species richness and altered flora composition, notably higher abundance of Bacteroidota, were observed in severe FC.
  • Metabolomic analysis revealed enrichment in L-isoleucine biosynthesis and glycolysis pathways, alongside decreased butyric acid in severe FC.

Conclusions:

  • Specific gut microbial compositions and metabolic pathways are associated with functional constipation severity.
  • Bacteroidota abundance and reduced butyric acid may serve as biomarkers for severe FC.
  • Identified flora and metabolic targets offer potential for novel diagnostic and therapeutic strategies in FC management.