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Raman spectroscopy for cell analysis: Retrospect and prospect
Wenjing Xu1, Wei Zhu1, Yukang Xia1
1School of Chemistry and Chemical Engineering, School of Bioengineering and Health, Wuhan Textile University, Wuhan, 430200, China.
Abstract:
Cell analysis is crucial to contemporary biomedical research, as it plays a pivotal role in elucidating life processes and advancing disease diagnosis and treatment. Raman spectroscopy, harnessing distinctive molecular vibrational data, provides a non-destructive method for cell analysis. This review surveys the progress of Raman spectroscopy in cellular analysis, emphasizing its utility in identifying individual cells, monitoring biomolecules, and assessing intracellular environments. A significant focus is placed on the novel application of triple-bond molecules as Raman tags, which enhance imaging capabilities by creating a distinctive signature with minimal background noise. The summary of Raman spectroscopy studies provides a forward-looking perspective on its applications.
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