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Appendectomy, acute appendicitis, and gastrointestinal diseases: A Mendelian randomization study.
Yi Zhao1, Xuecheng Bai1, Yi Ding1
1Department of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China; Academician (Expert) Workstation of Sichuan Province, Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Appendectomy and acute appendicitis influence gastrointestinal disease risk. Appendectomy is linked to colon cancer and primary sclerosing cholangitis, while appendicitis increases gallstone risk.
Area of Science:
- Gastroenterology and genetics research.
- Investigating the long-term health impacts of appendicitis and appendectomy.
Background:
- Appendectomy is the standard treatment for acute appendicitis.
- The long-term effects of appendectomy and acute appendicitis on gastrointestinal diseases remain unclear.
Purpose of the Study:
- To investigate the independent effects of appendectomy and acute appendicitis on the risk of various gastrointestinal diseases.
- Utilizing Mendelian randomization to analyze genetic associations.
Main Methods:
- Genome-wide significant genetic variants for appendectomy and acute appendicitis were identified as instrumental variables.
- Two-sample Mendelian randomization (MR) analyses were conducted.
- Univariate and multivariate MR models examined independent effects.
Main Results:
- Appendectomy was associated with an increased risk of colon cancer (OR, 1.54) and a decreased risk of primary sclerosing cholangitis (OR, 0.57).
- Acute appendicitis was linked to a higher risk of cholelithiasis (gallstones) (OR, 1.16).
- Results were significant after FDR correction.
Conclusions:
- Appendectomy and acute appendicitis may impact the risk of specific gastrointestinal diseases.
- Findings suggest potential links between appendiceal conditions/surgery and subsequent gastrointestinal health outcomes in European populations.
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