Digital gangrene without sclerodactyly in the presence of anticentromere antibodies: A unique presentation of scleroderma
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Anti-centromere antibody (ACA) associated digital necrosis can occur without connective tissue disease (CTD). This case highlights ACA-associated digital gangrene as a distinct autoimmune entity, even without scleroderma.
Area Of Science
- Rheumatology
- Vascular Medicine
- Autoimmunity
Background
- Peripheral vascular disorders linked to anti-centromere antibody (ACA) typically manifest with sclerodactyly within connective tissue disorders (CTD).
- ACA-associated digital necrosis usually occurs in patients with pre-existing Raynaud's phenomenon or vascular risk factors.
Observation
- A 60-year-old woman, a non-smoker with no diabetes, presented with isolated finger necrosis.
- The patient tested positive for ACA but showed no other signs of CTD.
Findings
- This case represents an unusual presentation of ACA-associated digital necrosis.
- The patient developed digital gangrene without typical preceding conditions like Raynaud's or other CTD features.
Implications
- This case emphasizes the need to consider autoimmune factors, specifically ACA, in the etiology of digital necrosis, even in the absence of overt CTD.
- It suggests that ACA-associated digital gangrene may be a distinct autoimmune disorder separate from scleroderma.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...