Carbohydrate polymer-driven nanoparticle synthesis and functionalization in the brain tumor therapy: A review

The brain tumors have been characterized with aggressive and heterogeneous nature. The treatment of brain tumors has been challenging due to their sensitive location and also, presence of blood-brain barrier (BBB) that reduces the entrance of bioactive compounds to the brain tissue. Therefore, the new treatment strategies should be focused on improving the efficacy of conventional therapeutics, crossing over biological barriers and introducing new kinds of methods for brain tumor elimination. In the recent years, the application of carbohydrate polymers in the treatment of human cancers has been increased as they possess biocompatibility, biodegradability and selective targeting of tumor cells. Moreover, carbohydrate polymer-based nanoparticles demonstrate desirable drug loading and encapsulation, making them suitable for the delivery of bioactive compounds. Accordingly, the carbohydrate polymers and their nanoparticles have been developed to improve the drug and gene delivery to brain tumors. Moreover, these nanoparticles can increase sensitivity of chemotherapy and immunotherapy. In addition to providing combination therapy, the carbohydrate polymer-based nanoparticles can elevate the phototherapy-mediated tumor ablation. These nanocarriers have demonstrated desirable particle size, zeta potential and encapsulation efficiency that are beneficial for brain tumor therapy. Moreover, these nanoparticles have high biocompatibility that can be subsequently utilized in clinical studies.