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Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

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Updated: Jun 6, 2025

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

Drug delivery using gold nanoparticles.

Lev Dykman¹, Boris Khlebtsov¹, Nikolai Khlebtsov²

¹Institute of Biochemistry and Physiology of Plants and Microorganisms, "Saratov Scientific Centre of the Russian Academy of Sciences", 13 Prospekt Entuziastov, Saratov 410049, Russia.

Advanced Drug Delivery Reviews

|December 1, 2024

Summary

This summary is machine-generated.

Functionalized gold nanoparticles (GNPs) offer efficient drug delivery for targeted cancer treatment. Their unique properties enable selective drug distribution and enhanced therapeutic effects, showcasing their potential in nanomedicine.

Keywords:

Antibiotics Anticancer drugs Biodistribution Cancer Conjugates Functionalization Gold nanoparticles Nanooncology Nucleic acids Theranostics

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Area of Science:

Nanotechnology
Materials Science
Pharmacology

Background:

Nanoparticles offer advanced drug delivery systems.
Gold nanoparticles (GNPs) possess unique size and surface properties.
Targeted drug delivery is crucial for effective disease treatment.

Purpose of the Study:

To review the use of functionalized gold nanoparticles (GNPs) as a drug delivery platform.
To highlight the potential of GNPs for targeted drug distribution.
To explore methods for enhancing drug delivery and efficacy using GNPs.

Main Methods:

Review of in vitro and in vivo studies on GNPs for drug delivery.
Analysis of GNP functionalization techniques (e.g., ligand coating).
Evaluation of photothermal properties of GNPs for therapeutic enhancement.

Main Results:

Functionalized GNPs demonstrate efficient and targeted drug delivery to biological sites, particularly tumors.
GNP surface modification allows for controlled drug release and improved selectivity.
Photothermal properties of GNPs can be leveraged to enhance pharmacological activity.

Conclusions:

Functionalized gold nanoparticles are a versatile platform for targeted drug delivery.
GNP characteristics can be tailored for enhanced efficacy and selectivity in cancer therapy.
Further research into GNPs holds promise for advancing nanomedicine and drug development.