Clinical evidence of acupuncture for amnestic mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials
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View abstract on PubMed
Summary
This summary is machine-generated.Acupuncture significantly improves cognitive function in individuals with amnestic mild cognitive impairment (aMCI). Further large-scale trials are needed to confirm these findings on acupuncture for aMCI.
Area Of Science
- Neurology
- Integrative Medicine
- Clinical Research
Background
- Amnestic mild cognitive impairment (aMCI) significantly increases dementia risk.
- Previous studies show acupuncture's effectiveness for MCI, but without differentiating aMCI subtypes.
- This meta-analysis specifically evaluates acupuncture's efficacy in aMCI patients.
Purpose Of The Study
- To systematically assess the efficacy of acupuncture for improving cognitive function in individuals with aMCI.
- To synthesize evidence from randomized controlled trials (RCTs) on acupuncture for aMCI.
Main Methods
- A comprehensive search of nine databases was conducted up to January 9, 2024.
- Risk of bias was assessed using the RoB 2.0 tool; data were analyzed using forest plots.
- Subgroup and sensitivity analyses were performed, with evidence certainty graded using GRADEpro GDT.
Main Results
- 15 RCTs with 908 aMCI participants were included.
- Acupuncture demonstrated significant improvements in cognitive assessments (MMSE, MoCA, ADAS-Cog) and P300 latency.
- Subgroup analysis indicated consistent efficacy between 4- and 8-week treatment durations; pooled results were robust, but evidence quality was low to very low.
Conclusions
- Acupuncture interventions are effective in ameliorating cognitive function in people with aMCI.
- Larger-scale, multicenter RCTs with standardized protocols and rigorous designs are necessary to confirm these findings.
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