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SR3677 IS HEPATOPROTECTIVE IN MURINE LIVER ISCHEMIA/REPERFUSION INJURY: POTENTIAL ROLE OF BNIP3L/NIX (BCL2/ADENOVIRUS
Avinash Naraiah Mukkala, Vida Maksimoska, Emma Noble1
1Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Unity Health Toronto; Toronto, Ontario, Canada.
Shock (Augusta, Ga.)
|December 1, 2024
Abstract:
SR3677, a highly selective rho-associated protein kinase 2 inhibitor, administered prior to liver ischemia/reperfusion injury, induced hepatoprotection in both wild-type and Parkin2-/- mice. Experiments in hepatocytes identified BNIP3L/NIX, as a potential mediator of the hepatoprotective effects of SR3677.
