APPLICATION OF TFPI2 IN SEPSIS SEVERITY PREDICTION

Area of Science:

• Biochemistry
• Immunology
• Critical Care Medicine

Background:

• Sepsis presents with infection and coagulation dysfunction.
• Tissue factor pathway inhibitor-2 (TFPI2) possesses antimicrobial and anticoagulant properties.
• The role of TFPI2 in sepsis severity and prognosis requires investigation.

Purpose of the Study:

• To assess the association between serum TFPI2 levels and sepsis severity.
• To determine the diagnostic and prognostic value of TFPI2 in sepsis.

Main Methods:

• Serum TFPI2 concentrations were measured in healthy controls, non-sepsis ICU patients, and sepsis patients.
• Correlation analysis was performed between TFPI2 levels and sepsis severity indicators.
• Logistic regression and ROC curve analysis evaluated TFPI2's predictive value for 28-day mortality.

Main Results:

• Sepsis patients had significantly higher serum TFPI2 levels than controls.
• TFPI2 levels correlated with sepsis severity scores (SOFA, APACHE II), lactate, coagulation markers (ISTH DIC, SIC), and platelet count.
• TFPI2 was identified as an independent risk factor for 28-day sepsis mortality (AUC=0.832).

Conclusions:

• Serum TFPI2 levels are elevated in sepsis and associated with disease severity.
• TFPI2 demonstrates significant potential as a biomarker for predicting sepsis severity and mortality.