APPLICATION OF TFPI2 IN SEPSIS SEVERITY PREDICTION

Introduction: Infection and coagulation dysfunction are two major features of sepsis, and TFPI2 exhibits both antimicrobial and anticoagulant properties. This study aims to evaluate whether TFPI2 is associated with the severity of sepsis, thereby determining its potential value in sepsis diagnosis and prognosis. Methods: Serum TFPI2 concentrations were measured and compared among 32 healthy controls, 16 intensive care unit (ICU) nonsepsis patients, and 106 ICU sepsis patients. Correlation analysis was performed between various indicators and TFPI2 levels in sepsis patients. Logistic regression analysis and receiver operating characteristic curves were used to assess the value of TFPI2 in predicting 28-day mortality in sepsis. Results: Sepsis patients exhibited markedly elevated serum TFPI2 levels compared with both healthy individuals and ICU patients without sepsis. Serum TFPI2 levels were significantly correlated with sepsis severity indicators such as Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation II score, Lac, coagulation markers including International Society on Thrombosis and Hemostasis overt disseminated intravascular coagulation criteria and Sepsis-Induced Coagulopathy scores, and platelet count. Univariate and multivariate logistic regression analyses revealed that TFPI2 is an independent risk factor for 28-day mortality in sepsis. The receiver operating characteristic curve showed that TFPI2 has a significant predictive value for 28-day mortality in sepsis, with an area under the curve of 0.832 and an optimal cutoff value of 8.316. Conclusions: This study indicates that serum TFPI2 levels hold promise as a biomarker for predicting the severity of sepsis.