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FUNCTIONAL IMMUNOPHENOTYPING FOR PRECISION THERAPIES IN SEPSIS.

Mahil Rao1, Patrick W McGonagill2, Scott Brackenridge3

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Shock (Augusta, Ga.)
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Sepsis survivors often face persistent inflammation and immune suppression, increasing infection risk. Identifying individual immune endotypes can guide personalized therapies for better sepsis treatment outcomes.

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Area of Science:

  • Immunology
  • Critical Care Medicine
  • Genomics

Background:

  • Sepsis is a leading cause of death globally, with survivors frequently experiencing long-term immune dysfunction.
  • Current sepsis treatments lack personalization, leading to suboptimal outcomes due to diverse patient immune responses.

Purpose of the Study:

  • To review current methods for defining individual immune states (endotypes) in sepsis.
  • To propose using immune endotyping for prescreening patients to optimize therapeutic selection.

Main Methods:

  • Review of existing literature on sepsis immunology and host response.
  • Analysis of technologies for immune profiling and endotyping.

Main Results:

  • Sepsis impacts immune pathways differently across individuals and over time.
  • Immune endotyping is crucial for predicting treatment response in sepsis.

Conclusions:

  • Personalized medicine approaches, guided by immune endotyping, are essential for improving sepsis patient care.
  • Prescreening sepsis patients based on their immune endotype can enhance the efficacy of targeted therapies.