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Reduced kidney function elevates venous thromboembolism (VTE) risk, especially when combined with genetic susceptibility. Renal function biomarkers can predict VTE in at-risk individuals.

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Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Genetics

Background:

  • The relationship between impaired renal function and venous thromboembolism (VTE) risk is debated.
  • Understanding the interplay between renal function, genetic predisposition, and VTE is crucial for large populations.

Purpose of the Study:

  • To investigate the association between renal function and the incidence of VTE.
  • To explore the combined impact of renal function and genetic susceptibility on VTE risk.

Main Methods:

  • Utilized UK Biobank data from 358,723 participants without renal failure.
  • Employed Cox proportional hazards models and Kaplan-Meier curves to analyze renal function and VTE risk.
  • Assessed the interaction between renal function biomarkers and genetic susceptibility for VTE onset.

Main Results:

  • Elevated levels of urine creatinine, serum creatinine, urea, urate, cystatin C, urine microalbumin, and lower estimated glomerular filtration rate (eGFR) were linked to increased VTE risk.
  • Participants with both poor renal function (low eGFR) and high genetic risk showed significantly higher VTE risk (HRs ranging from 2.49 to 3.52).

Conclusions:

  • Decreased renal function is an independent risk factor for VTE.
  • Genetic susceptibility has an additive effect on VTE risk in individuals with impaired renal function.
  • Renal function biomarkers may serve as predictive indicators for VTE, particularly in genetically susceptible individuals.