Does indocyanine green fluorescence angiography reduce the risk of anastomotic leaks in colorectal resections? A systematic review and meta-analysis of randomized controlled trials
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View abstract on PubMed
Summary
This summary is machine-generated.Indocyanine green fluorescence angiography (ICG-FA) significantly reduces overall anastomotic leaks in colorectal surgery by 45%. This method shows particular promise for preventing grade A leaks, though its impact on other outcomes requires further investigation.
Area Of Science
- Colorectal Surgery
- Surgical Innovation
- Medical Imaging
Background
- Anastomotic leaks are a major complication following colorectal surgery.
- Indocyanine green fluorescence angiography (ICG-FA) is a novel technique proposed to mitigate this risk.
- Existing evidence requires synthesis to clarify ICG-FA's efficacy.
Purpose Of The Study
- To evaluate the effectiveness of ICG-FA in reducing anastomotic leaks after colorectal surgery.
- To analyze the impact of ICG-FA on overall and specific grades of anastomotic leaks.
- To assess ICG-FA's influence on secondary surgical outcomes.
Main Methods
- A meta-analysis adhering to PRISMA guidelines was conducted.
- Five randomized controlled trials (RCTs) involving 1369 patients were included.
- Data were extracted and analyzed using comprehensive meta-analysis software.
Main Results
- ICG-FA was associated with a 45% reduction in overall anastomotic leaks (OR: 0.550, p=0.012).
- A significant reduction was observed for grade A leaks (OR: 0.31, p=0.008), with a trend for low anastomoses.
- No significant differences were found for blood loss, surgery duration, hospital stay, mortality, or surgical site infections.
Conclusions
- ICG-FA is effective in reducing the overall incidence of anastomotic leaks in colorectal surgery.
- The technique shows particular benefit in preventing less severe (grade A) leaks.
- Further high-quality RCTs are warranted to confirm these findings and explore potential benefits in secondary outcomes.
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