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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Updated: Jun 20, 2026

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Published on: August 27, 2014

Polymorphing Hydrogels Regulated by Photo-reactive DNA Cross-links.

Junho Roh¹, Seongjun Park¹, Hoeseong Kim¹

¹School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), 123, Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea.

Advanced Materials (Deerfield Beach, Fla.)

|December 2, 2024

Summary

This summary is machine-generated.

Researchers developed new polymorphing hydrogels that change shape on demand using patterned light. These advanced DNA-cross-linked materials offer precise, programmable control for soft machines.

Keywords:

4D printing microfabrication photo‐reactive DNA cross‐links polymorphing hydrogels soft actuators

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Area of Science:

Materials Science
Polymer Chemistry
Biotechnology

Background:

Traditional shape-morphing hydrogels have pre-determined capabilities.
Current polymorphing hydrogels require complex steps or lack sustained responsiveness.

Purpose of the Study:

To present photo-reactive DNA-cross-linked polymorphing hydrogels.
To enable programmable shape morphing using patterned light.

Main Methods:

Utilizing photo-reactive DNA cross-links that respond to light wavelengths.
Employing a one-pot reaction for hydrogel fabrication.
Implementing patterned light for spatiotemporal control.

Main Results:

Achieved precise and dynamic shape morphing of hydrogels.
Demonstrated reprogrammable features and sustained responsiveness.
Enabled on-demand structural changes via light stimuli.

Conclusions:

Developed a novel class of polymorphing hydrogels with high programmability.
Photo-reactive DNA cross-links offer precise control over hydrogel shape.
These hydrogels present advanced solutions for multifunctional soft machines and complex applications.