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Updated: Jun 6, 2025
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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
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Microbial biosynthesis of nucleos(t)ide analogs: applications, and engineering optimization.
Wenbin Yu1, Xiang Wei2, Yichuan Wu1
1Key Laboratory of Natural Microbial Medicine Research of Jiangxi Province, College of Life Sciences, Jiangxi Science & Technology Normal University, Nanchang, China.
Critical Reviews in Microbiology
|December 2, 2024
Summary
Nucleos(t)ide analogs are vital compounds used in medicine and food. Microbial engineering optimizes their production, enhancing diversity and bioactivity for drug discovery and biotechnology advancements.
Area of Science:
- Biotechnology
- Medicinal Chemistry
- Synthetic Biology
Background:
- Nucleos(t)ide analogs are critical compounds derived from nucleosides and nucleotides.
- They possess diverse applications, including roles as antiviral, anticancer agents, and food additives.
- Their value spans medical research, drug discovery, and biotechnology.
Purpose of the Study:
- To review the broad applications of nucleos(t)ide analogs.
- To discuss advancements in engineering and optimization for improved production.
- To highlight the role of microbial cell factories in synthesizing these compounds.
Main Methods:
- Leveraging microbial biosynthesis pathways for analog production.
- Employing metabolic engineering strategies to optimize synthesis.
- Designing microbial cell factories for enhanced yield and diversity.
Main Results:
- Optimization of nucleos(t)ide analog synthesis pathways.
- Enhanced production efficiency and diversity of nucleos(t)ide analogs.
- Creation of novel analogs with improved bioactivity and therapeutic potential.
Conclusions:
- Microbial cell factories are key to efficient nucleos(t)ide analog production.
- Metabolic engineering significantly advances analog synthesis and discovery.
- These developments drive progress in drug discovery and biotechnology.
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