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Related Concept Videos

Electrocardiogram01:29

Electrocardiogram

2.2K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
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Electrocardiogram Fundamentals01:28

Electrocardiogram Fundamentals

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Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
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Cardiac Action Potential01:30

Cardiac Action Potential

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Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
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ECG Interpretation of Rhythms01:24

ECG Interpretation of Rhythms

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An electrocardiogram (ECG)graphically represents the heart's electrical activity on ECG paper or a monitor.
Components of the Electrocardiogram
The primary components of a normal ECG waveform in Normal sinus rhythm(NSR) include the P wave, PR interval, QRS complex, ST segment, T wave, and occasionally a U wave.
ECG waveforms are divided by vertical and horizontal lines at standard intervals.
The horizontal axis measures time and rate, and the vertical axis measures amplitude or voltage....
498
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

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The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
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Related Experiment Video

Updated: Jun 6, 2025

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
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Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

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CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients.

Ksenia Sedova1,2, Jan E Azarov1, Peter M Van Dam3

  • 1Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic.

Journal of Cardiovascular Electrophysiology
|December 2, 2024
PubMed
Summary

Cardiac resynchronization therapy (CRT) non-responders may benefit from optimized lead placement. Novel CineECG repolarization parameters show promise in predicting acute hemodynamic responses in CRT patients.

Keywords:
cardiac resynchronization therapyheart failurehemodynamicsmultipoint pacingmultisite pacingrepolarization

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

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Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Cardiac resynchronization therapy (CRT) has variable response rates, necessitating optimization of left ventricular (LV) lead placement and device programming.
  • CineECG offers a novel approach for spatial visualization and quantification of myocardial electrical activity.

Purpose of the Study:

  • To evaluate CineECG-derived parameters across different pacing modes.
  • To assess the association between CineECG parameters and acute hemodynamic responses in CRT patients.

Main Methods:

  • CineECG was utilized to map the average electrical path from a 12-lead ECG in 15 patients with nonischemic dilated cardiomyopathy and left bundle branch block.
  • Analysis included CineECG path directions for QRS and ST-T intervals (Xh, Yh, Zh axes) and LV dP/dt max measurements under various LV lead positions.

Main Results:

  • The ST-T path direction Yh was independently associated with increased dP/dt max during CRT (p=0.006).
  • ROC analysis indicated ST-T path direction Yh predicted a 10% increase in dP/dt max (AUC: 0.779, p=0.002), with an optimal cutoff > 0.084.

Conclusions:

  • Specific CineECG repolarization sequence parameters correlate with acute hemodynamic response in CRT patients.
  • These CineECG parameters warrant further investigation as potential predictors of long-term clinical outcomes in CRT.