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Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
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Expansive Arterial Remodeling and Its Risk Factors in Cerebral Infarction: A Retrospective Study

Bingzheng Gong1, Ying Pian, Qichao Yang

  • 1Second Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China.

The Neurologist
|December 2, 2024
PubMed

Insights

Patients with cerebral infarction (CI) show larger carotid artery and aortic arch diameters. Arterial plaque features predict this expansive remodeling, suggesting early plaque detection and intervention may prevent CI.

Area of Science:

  • Vascular Medicine
  • Neurology
  • Cardiology

Background:

  • Cerebral infarction (CI) is a common condition with uncertain links to carotid artery remodeling.
  • Understanding arterial remodeling is crucial for CI prevention and treatment.

Purpose of the Study:

  • Investigate the association between carotid artery system and aortic arch (AA) remodeling and CI.
  • Determine the significance of arterial remodeling in CI pathogenesis.

Main Methods:

  • Retrospective analysis of computed tomography angiography data from 821 patients.
  • Statistical comparison of arterial dimensions and plaque characteristics between CI and non-CI groups.

Main Results:

  • Significantly greater diameters of common carotid artery (CCA), internal carotid artery (ICA), carotid bifurcation, and AA in the CI group (P <0.05).
  • Carotid sinus plaque (CSP) number and aortic arch plaque (AAP) length predicted CCA remodeling.
  • AAP thickness predicted AA remodeling.

Conclusions:

  • CI patients exhibit increased carotid system and AA diameters, linked to arterial plaque features.
  • Early detection of arterial plaques and interventions targeting expansive remodeling may aid CI prevention and treatment.
Abstract

Keywords:
ROC curvearterial remodelingatherosclerosiscerebral infarctioncomputed tomography angiographyplaque

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