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Published on: August 7, 2017
Evaluation of Pentraxin-3 levels in children with multisystem inflammatory syndrome
Dolunay Gürses1, Münevver Yılmaz1, Esin Avcı2
1Department of Pediatric Cardiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Insights
Elevated Pentraxin-3 levels in children with multisystem inflammatory syndrome indicate cardiac involvement and predict disease severity. Higher Pentraxin-3 levels correlate with poorer cardiac function, aiding early diagnosis and management.
Area of Science:
- Pediatric Cardiology
- Inflammatory Diseases
- Biomarker Research
Background:
- Early recognition of cardiac involvement is crucial for managing multisystem inflammatory syndrome (MIS).
- Predicting disease prognosis in MIS is essential for effective patient care.
- Pentraxin-3 (PTX-3) is investigated as a potential biomarker for cardiac complications in MIS.
Purpose of the Study:
- To determine the role of Pentraxin-3 levels in identifying cardiac involvement in MIS patients.
- To evaluate the association between Pentraxin-3 levels and disease severity in MIS.
- To assess Pentraxin-3 as a predictive marker for clinical outcomes in MIS.
Main Methods:
- A cohort of 56 MIS patients and 26 healthy children was studied.
- MIS patients were categorized by cardiac involvement and disease severity (mild-moderate vs. severe).
- Plasma Pentraxin-3 levels were measured in all participants before treatment.
Main Results:
- MIS patients exhibited significantly higher Pentraxin-3 levels compared to controls.
- Elevated Pentraxin-3 levels were associated with cardiac involvement and severe disease.
- Pentraxin-3 levels correlated negatively with left ventricular ejection fraction and positively with B-type natriuretic peptide and troponin.
Conclusions:
- Increased Pentraxin-3 levels may serve as a valuable predictor of cardiac involvement in MIS.
- Pentraxin-3 levels show potential in forecasting the clinical course and severity of MIS.
- Further large-scale prospective studies are warranted to confirm these findings.
Background:
Early recognition of cardiac involvement and prediction of disease prognosis are essential for the management of inflammatory diseases such as multisystem inflammatory syndrome. This study aimed to investigate the role of Pentraxin-3 levels in identifying cardiac involvement and evaluating disease severity in patients with multisystem inflammatory syndrome.
Methods:
The study included 56 multisystem inflammatory syndrome patients and 26 healthy children as a control group. The multisystem inflammatory syndrome group was divided into those with cardiac involvement (n = 34) and those without (n = 22), as well as those with clinically mild-moderate (n = 30) and severe (n = 26) multisystem inflammatory syndrome. Blood samples for measurement of Pentraxin-3 levels were obtained from all patients before treatment and from the healthy controls.
Results:
In the patient group, the mean age was 8.2 ± 4 years (range: 2-17 years), and the male-to-female ratio was 1.8. In the control group, these values were 9.5 ± 3.7 years (range: 2-16 years) and 1.9, respectively (p > 0.05). Plasma Pentraxin-3 levels were significantly higher in multisystem inflammatory syndrome patients compared to controls (7.1 ± 5 ng/mL vs. 2.9 ± 2.1 ng/mL, p = 0.001). Patients with cardiac involvement had a significantly higher median Pentraxin-3 level than those without (5.8 ng/mL vs. 4.1 ng/mL, p = 0.004). Severe disease was also associated with a higher median Pentraxin-3 level compared to mild-moderate disease (6.1 ng/mL vs. 4.4 ng/mL, p = 0.001). Pentraxin-3 level was negatively correlated with left ventricular ejection fraction and positively correlated with B-type natriuretic peptide, troponin.
Conclusion:
Elevated Pentraxin-3 levels in multisystem inflammatory syndrome patients may help predict the clinical course of the disease and cardiac involvement. However, larger-scale prospective studies are needed to further elucidate this.
