Successfully Managed Toxic Megacolon Due to Clostridium difficile Infection in a Pheochromocytoma Patient Complicated...

In recent years, there has been a significant rise in both the frequency and severity of Clostridium difficile colitis. This infection presents a broad clinical spectrum, ranging from asymptomatic colonization to severe fulminant colitis, which often requires urgent surgical intervention. The failure of medical treatments and the development of toxic megacolon typically necessitate surgery, though it is associated with high mortality rates. In this case, we successfully managed a rare instance of fulminant colitis in a pheochromocytoma patient with complicated cardiogenic and septic shock through conservative therapy, utilizing the standard vancomycin-metronidazole combination, supplemented with rifaximin.