Clinical Features of Candida Catheter-related Bloodstream Infections and Persistent Infections Associated with Early Catheter Reinsertion: A 6-year Retrospective Study
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View abstract on PubMed
Summary
This summary is machine-generated.Catheter-related persistent Candida infections (CRPCI) are linked to early reinsertion of new catheters after Candida bloodstream infections (CRBSI). Prompt catheter replacement increases the risk of persistent fungemia, highlighting the need for careful timing.
Area Of Science
- Infectious Diseases
- Medical Microbiology
- Clinical Medicine
Background
- Catheter-related persistent Candida infections (CRPCI) can arise from colonization of new catheters following Candida catheter-related bloodstream infections (CRBSI).
- The optimal timing for inserting new catheters after CRBSI is not well-established and remains a clinical concern.
- Understanding the clinical features of CRBSI and CRPCI is crucial for patient management.
Purpose Of The Study
- To investigate the clinical characteristics of Candida bloodstream infections (CRBSI).
- To identify factors associated with catheter-related persistent Candida infections (CRPCI).
- To evaluate the impact of new catheter insertion timing on CRPCI development.
Main Methods
- Retrospective analysis of hospitalized patients diagnosed with Candida CRBSI between 2015 and 2020.
- Definition of CRPCI as the growth of the same Candida species from a newly inserted catheter tip post-CRBSI.
- Statistical comparison using Chi-squared and Fisher's exact tests.
Main Results
- Fifty-four percent of patients with CRBSI received total parenteral nutrition.
- CRPCI developed in 48% of patients with new catheter cultures, showing a significantly higher incidence of persistent fungemia (50% vs. 9.1%).
- Patients with CRPCI had a significantly shorter interval between infected catheter removal and new catheter reinsertion (0.27 days vs. 3.08 days).
Conclusions
- Total parenteral nutrition is a potential risk factor for Candida CRBSI.
- CRPCI is associated with a higher likelihood of persistent fungemia.
- Early reinsertion of a new catheter after infected catheter removal may increase the risk of CRPCI.
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