Total serum bilirubin levels as mediators of anti-atherosclerosis mechanisms with consideration of smoking status
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View abstract on PubMed
Summary
This summary is machine-generated.Smokers have lower total serum bilirubin (TSB) levels, which may increase atherosclerotic cardiovascular disease (ASCVD) risk by promoting inflammation. Smoking cessation can increase TSB and reduce inflammation, potentially lowering ASCVD risk.
Area Of Science
- Biochemistry
- Cardiovascular Medicine
- Public Health
Background
- Cigarette smoking is a major risk factor for atherosclerotic cardiovascular diseases (ASCVDs).
- Mildly elevated total serum bilirubin (TSB) levels possess anti-atherosclerotic and anti-inflammatory properties.
- The interplay between TSB levels, smoking, and inflammation requires further investigation.
Purpose Of The Study
- To investigate the association between smoking status and total serum bilirubin (TSB) levels.
- To explore the relationship between TSB levels, smoking, and markers of inflammation.
- To determine if TSB mediates the effect of smoking on inflammation.
Main Methods
- A cross-sectional study of 8337 health screening participants without a history of ASCVD.
- Comparison of TSB levels between smokers and non-smokers using Kruskal-Wallis test.
- Multivariable logistic regression and mediation analysis to assess the influence of smoking on TSB and inflammation.
Main Results
- Smokers exhibited significantly lower TSB levels compared to non-smokers (p<0.0001).
- Smoking was an independent determinant of lower TSB levels (AOR=0.81, p=0.003).
- Higher TSB levels correlated with decreased leukocyte counts and C-reactive protein (CRP) levels, and mediation analysis showed smoking indirectly increased inflammation.
Conclusions
- Lower TSB levels in smokers may contribute to increased ASCVD risk via heightened inflammation.
- TSB may play a role in regulating inflammation and exerting antioxidant effects.
- Smoking cessation is associated with increased TSB levels and reduced inflammation, potentially mitigating ASCVD risk.
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