Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfaction01:25

Olfaction

40.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
40.5K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

10.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.5K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

13.1K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
13.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crystalloid fluids choices during cardiopulmonary bypass, outcomes of acid-base and lactate levels in cardio surgery.

BMC anesthesiology·2026
Same author

Improvements in Time-Sensitive Stroke Care and Alteplase Administration: The Iranian Comprehensive Code Stroke Management Program (ICSM Phase III).

Stroke·2026
Same author

Correction to: Potential genetic polymorphism of matrix metalloproteinase (MMP)‑9 in Iranian migraine patients with Toxoplasma gondii infection.

Parasitology research·2026
Same author

Comparison of Two Auditory-Perceptual Evaluation Indexes, CAPE-V and GRBAS (Machine Learning), in Patients With Parkinson's Disease.

Journal of voice : official journal of the Voice Foundation·2025
Same author

Comparison of electrical activity and ultrasonographic dimension of the cervical spine muscles in patients with cervical lateral spinal stenosis and asymptomatic controls.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2025
Same author

Updated Protocol for Stroke Code Management in Prehospital Settings: The Iranian Comprehensive Stroke Code Management Program (ICSCM Phase II).

Archives of academic emergency medicine·2025

Related Experiment Video

Updated: May 5, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

21.9K

Olfactory dysfunction in COVID-19; Self-report or olfactory dysfunction test?

Elham Sahebalzamani1, Shayan Alijanpour2, Payam Saadat3

  • 1Student Research Committee, Babol University of Medical Sciences, Babol, Iran.

Caspian Journal of Internal Medicine
|December 2, 2024
PubMed
Summary

COVID-19 olfactory dysfunction differs between self-reports and specific tests. Standardized smell tests offer more reliable COVID-19 smell disorder assessments than self-reporting.

Keywords:
AnosmiaCOVID-19SARS-CoV-2Smell

More Related Videos

A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.6K
Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests
04:00

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests

Published on: September 13, 2024

740

Related Experiment Videos

Last Updated: May 5, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

21.9K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.6K
Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests
04:00

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests

Published on: September 13, 2024

740

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Epidemiology

Background:

  • COVID-19 commonly causes sudden-onset smelling disorders.
  • Assessing olfactory dysfunction in COVID-19 patients involves self-reports or specific tests.
  • The reliability of self-reported versus objective smell testing requires investigation.

Purpose of the Study:

  • To compare the prevalence and reliability of smell disorders in COVID-19 patients using self-reported data versus objective testing.
  • To determine if quantitative smell tests show significant differences compared to patient self-assessments.

Main Methods:

  • A systematic review of 554 studies (Dec 2019-Sep 2020) using PICO and MeSH terms.
  • Searches conducted across Web of Science, Scopus, and PubMed databases.
  • Studies categorized into self-report (33 articles) and specific-test (9 articles) groups after excluding duplicates.

Main Results:

  • 80% of studies relied on self-reported olfactory dysfunction, while 20% used specific tests.
  • Self-reported prevalence varied widely (20%-97%), with limited validity/reliability data.
  • Specific tests indicated higher anosmia incidence (>65%, up to 98%), with better reported validity and reliability.

Conclusions:

  • Self-reported smell loss in COVID-19 can be influenced by sociodemographic factors.
  • Standardized smell tests provide more reliable and professional assessments than self-reporting.
  • Objective, standardized testing is recommended for accurate COVID-19 smell disorder screening.