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Related Experiment Video

Updated: Jun 6, 2025

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter

Published on: April 22, 2014

Thermal bubble single-cell printing chip: High-throughput, wide-field, and efficient.

Bo Deng¹, Kun Wang², Peng Huang²

¹School of Microelectronics, Shanghai University, Shanghai 201800, China.

Biomicrofluidics

|December 2, 2024

Summary

This summary is machine-generated.

A novel thermal inkjet chip enables high-throughput single-cell printing, overcoming limitations of current methods. This technology accelerates single-cell analysis for cell biology and disease research.

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Last Updated: Jun 6, 2025

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter

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Published on: April 22, 2014

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

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Published on: January 10, 2017

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

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Published on: May 12, 2008

Area of Science:

Biotechnology
Cell Biology
Bioengineering

Background:

Single-cell printing is crucial for understanding cell biology and disease.
Existing methods face challenges with low throughput, limited field of view, and inefficiency.

Purpose of the Study:

To develop an innovative single-cell printing chip using thermal inkjet technology.
To address the limitations of throughput, field of view, and efficiency in current single-cell printing.

Main Methods:

Utilized a high-density thermal foam-based inkjet nozzle array on a chip.
Integrated high-speed cameras and computer vision for optical image capture and cell identification.
Employed thermal bubble technology for precise single-cell deposition.

Main Results:

Achieved high-throughput, wide-field, and efficient single-cell printing.
Demonstrated successful printing of Chinese hamster ovary and human embryonic kidney 293 cells.
Printed a single 96-well plate in 2-3 minutes, enabling multi-plate processing.

Conclusions:

The developed thermal bubble single-cell printing chip is a viable platform for high-throughput single-cell analysis.
This technology significantly enhances efficiency and scalability for cell-based research.
The system facilitates rapid and uninterrupted processing of multiple plates.