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Updated: Jun 6, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Targeting regulated cell death pathways in cancers for effective treatment: a comprehensive review

Ruchi Saxena1, Craig M Welsh2, You-Wen He1

  • 1Department of Integrative Immunobiology, Duke University School of Medicine, Durham, United States.

Frontiers in Cell and Developmental Biology
|December 2, 2024
PubMed

Insights

Targeting cancer

Area of Science:

  • Oncology
  • Cell Biology

Background:

  • Cancer cells evade programmed cell death, promoting uncontrolled proliferation.
  • Dysregulation of multiple cell death pathways (apoptosis, necroptosis, ferroptosis, etc.) is critical for cancer advancement.

Purpose of the Study:

  • To review recent advances in targeting cancer cell death pathways for therapeutic development.
  • To highlight the importance of targeting "mission-critical" events that prevent tumor cell death.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of molecular and cellular mechanisms of regulated cell death in cancer.

Main Results:

  • Dysregulated cell death pathways are key drivers of cancer progression.
  • Targeting these pathways offers promising therapeutic strategies.
  • Preclinical and clinical developments show potential for novel cancer treatments.

Conclusions:

  • Understanding regulated cell death pathways is crucial for effective cancer therapy.
  • Targeting specific cell death evasion mechanisms can lead to impactful, personalized cancer treatments with fewer side effects.
Keywords:
apoptosisautophagycancer therapycuproptosisferroptosisnecroptosispyroptosisregulated cell death pathway

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