Efficacy of a Postbiotic Formulation Combined With Microneedling for Mild-to-Moderate Acne: A Self-Control Study

Area of Science:

• Dermatology
• Microbiology
• Cosmetic Science

Background:

• Acne vulgaris affects many globally, with rising antibiotic resistance limiting traditional treatments.
• Non-pharmacological methods like microneedling are emerging alternatives.
• Postbiotics are gaining attention for acne management, but their combination with microneedling lacks evidence.

Purpose of the Study:

• To evaluate the effectiveness of a postbiotic formulation used with microneedling for mild-to-moderate facial acne vulgaris.

Main Methods:

• Twenty Chinese patients with acne vulgaris received one combined treatment.
• Patients were monitored for 4 weeks post-treatment.
• Evaluations included symptom improvement, safety, and patient satisfaction.

Main Results:

• Global Acne Grading System scores reduced by over 50%.
• Clinical photos showed improved skin lesions and brighter skin tone.
• VISIA analysis indicated significant improvements in speckle, pores, redness, and porphyrins, with no adverse reactions and over 85% patient satisfaction.

Conclusions:

• The combination of postbiotics and microneedling may restore skin barrier function and microbial balance.
• This approach shows potential for reducing inflammation and treating acne lesions.
• It presents a promising therapeutic strategy for acne vulgaris prevention and management.