Related Experiment Video
Updated: Jun 6, 2025
07:57
Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry
Published on: December 26, 2019
12.1K
Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity
Muye Ma1, Yongliang Zhang2,3, Kanyi Pu4,5
1Department of Diagnostic Radiology, Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, Singapore, 117597, Singapore. wei.tang@nus.edu.sg.
Chemical Society Reviews
|December 2, 2024
Summary
Nanoparticles can reprogram tumor metabolism to enhance cancer immunotherapy. This approach targets the tumor microenvironment to improve T-cell function and boost anti-cancer immunity.
Area of Science:
- Oncology
- Immunology
- Nanotechnology
- Metabolic Engineering
Background:
- Cancer immunotherapies aim to enhance T-cell-mediated anti-tumor immunity.
- Tumor microenvironment (TME) metabolism reprogramming hinders immune cell function and limits immunotherapy efficacy.
- Targeting distinct metabolic needs of tumor and immune cells is crucial for optimizing therapeutic outcomes.
Purpose of the Study:
- To review nanotherapeutic strategies for modulating tumor metabolism to enhance cancer immunotherapy.
- To explore the design principles of nanoplatforms for immunometabolic modulation.
- To discuss the potential of nanotechnology in advancing cancer immunotherapy.
Main Methods:
- Review of current literature on nanotherapeutics and immunometabolism.
- Analysis of nanomaterial design for targeted metabolic intervention.
- Examination of key metabolic pathways in the TME and their regulation.
Main Results:
- Nanotherapeutics offer a promising avenue for precise metabolic modulation in the TME.
- Tailored metabolic interventions via nanoplatforms can enhance the cancer-immunity cycle.
- Targeting tumor metabolism can overcome key challenges in current cancer immunotherapy.
Conclusions:
- Emerging immunometabolic modulatory nanotechnology holds significant promise for cancer immunotherapy.
- Nanotechnology-based metabolic modulation represents a new frontier in overcoming immunotherapy resistance.
- Future nanomedicines could offer selective targeting for improved cancer treatment outcomes.
Related Concept Videos
01:27Tumor Immunotherapy
476
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
476
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:27Cytotoxic T Cells-mediated Immune Response
846
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
846
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K