Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.1K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.1K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

12.2K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
12.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Boosting Permanganate-Initiated Pollutant Polymerization via Synergistic Dual-Oxidant Activation by In Situ-Formed Nascent MnO<sub>2</sub>.

Environmental science & technology·2026
Same author

Cation-π and Electrostatic Interplay in Ultraselective Polymeric Nanofluidics for Exceptional Osmotic Energy Conversion Efficiency.

Journal of the American Chemical Society·2026
Same author

Anomalous ion flows in boron nitride nanotube arrays.

Nature nanotechnology·2026
Same author

Actual Visualization of Mechanical Mapping via <i>Hofmeister</i> Effect-Regulated Elastic Structure-Colors.

Analytical chemistry·2026
Same author

A general method for synthesizing heteropore covalent organic framework membranes to rapidly enrich uranyl ions.

Nature communications·2026
Same author

Shadow-Calibrated Stereo Vision for Colorimetric Sweat Analysis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Video

Updated: Jun 6, 2025

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
08:07

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Published on: March 9, 2019

7.7K

Thrombin Nanochannel Logic Gate Inspired by BioMemory.

Yonghuan Chen1, Xinru Yue1, Yongtao Tang1

  • 1College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Speed Capability Research, Su Bingtian Center for Speed Research and Training, Jinan University, Guangzhou 510632, China.

Analytical Chemistry
|December 2, 2024
PubMed
Summary

This study demonstrates a novel nanochannel biosensing system for biomemory applications. It achieves highly sensitive thrombin detection and biomemory reading at the hardware level using DNA aptamers and logic gates.

More Related Videos

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.3K
Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
12:20

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

Published on: July 22, 2013

18.2K

Related Experiment Videos

Last Updated: Jun 6, 2025

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
08:07

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Published on: March 9, 2019

7.7K
Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.3K
Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
12:20

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

Published on: July 22, 2013

18.2K

Area of Science:

  • Biophysics
  • Nanotechnology
  • Molecular Biology

Background:

  • Biomemory relies on electrical signals and ion channels, similar to solid-state nanochannels.
  • Nanochannels can simulate neuron behavior by controlling ion flow for information transmission.

Purpose of the Study:

  • To develop a functionalized nanochannel sensing system for biomemory applications.
  • To achieve sensitive detection and controlled response of target molecules.
  • To link molecular events with memory storage and recognition at the hardware level.

Main Methods:

  • Constructed a nanochannel sensing system using DNA aptamers targeting thrombin (Thr).
  • Utilized Watson-Crick base pairing and chain displacement reactions for controlled molecular release and response.
  • Implemented a Thr-nanochannel logic gate to establish input-output relationships for biomemory reading.

Main Results:

  • Achieved highly sensitive thrombin detection with a limit of 0.221 fM.
  • Demonstrated controlled release and cyclic response of the target molecule.
  • Successfully realized biomemory reading at the hardware level through the developed logic gate.

Conclusions:

  • The developed biological hybrid nanofluidic device converts molecular events into electrical signals.
  • This system offers potential for connecting biomemory mechanisms with nanochannel biosensing and recognition.
  • Paves the way for future advancements in biomemory hardware and biosensing technologies.