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A hypertensive adolescent with aripiprazole-induced hyperaldosteronism
Pelin Abdal Yıldırım1, Eren Soyaltın2,3, Cemaliye Başaran2,3
1Department of Pediatrics, Division of Nephrology, Izmir City Hospital, Izmir, Turkey. pelinabdal@outlook.com.
Pediatric Nephrology (Berlin, Germany)
|December 2, 2024
Summary
Aripiprazole may cause hypertension and hyperaldosteronism in adolescents, as seen in a 16-year-old male. Symptoms resolved after discontinuing the antipsychotic medication.
Area of Science:
- Pharmacology
- Cardiology
- Endocrinology
Background:
- Aripiprazole is an antipsychotic medication used for mental health conditions.
- Hypertension is a known, though not fully understood, side effect of aripiprazole.
- The underlying mechanisms of aripiprazole-associated hypertension require further investigation.
Purpose of the Study:
- To present a case study of a 16-year-old male who developed hypertension after aripiprazole use.
- To explore potential mechanisms linking aripiprazole to hypertension and hyperaldosteronism.
Main Methods:
- Case report of a 16-year-old male patient presenting with headache and hypertension.
- Evaluation of aldosterone/plasma renin activity (PRA) levels.
- Monitoring of blood pressure and hormonal levels after aripiprazole discontinuation.
Main Results:
- The patient exhibited elevated aldosterone/PRA levels concurrently with hypertension.
- Hypertension and hyperaldosteronism resolved after the cessation of aripiprazole.
- Aldosterone/PRA levels normalized upon follow-up after drug withdrawal.
Conclusions:
- Aripiprazole may be associated with hypertension and secondary hyperaldosteronism in adolescent patients.
- The findings suggest a potential link between aripiprazole and the renin-angiotensin-aldosterone system.
- Further research is warranted to elucidate the precise mechanisms of this adverse effect.
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