Long-term survival after sleeve lobectomy versus pneumonectomy for non-small cell lung cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Sleeve lobectomy offers similar short-term mortality and better long-term survival than pneumonectomy for centrally located non-small cell lung cancer (NSCLC). This makes sleeve lobectomy the preferred surgical option when feasible.
Area Of Science
- Thoracic Surgery
- Surgical Oncology
- Pulmonary Medicine
Background
- Central non-small cell lung cancer (NSCLC) presents unique surgical challenges.
- Sleeve lobectomy and pneumonectomy are surgical options for centrally located NSCLC.
- Comparative data on short-term and long-term outcomes are crucial for treatment decisions.
Purpose Of The Study
- To compare short-term mortality and long-term overall survival.
- To evaluate sleeve lobectomy versus pneumonectomy for resectable, central NSCLC.
- To determine the optimal surgical approach for this patient population.
Main Methods
- Retrospective review of 109 patients undergoing sleeve lobectomy (2009-2023).
- Propensity score matching with 60 pneumonectomy patients from a national registry.
- Comparison of 30/90-day mortality and long-term overall survival using statistical tests.
Main Results
- No significant difference in 30- and 90-day mortality between sleeve lobectomy and pneumonectomy groups.
- Sleeve lobectomy demonstrated significantly longer overall survival in both unmatched (HR 0.52) and matched (HR 0.55) cohorts.
- 5-year overall survival was 68% (sleeve lobectomy) vs. 49% (pneumonectomy) unmatched, and 61% vs. 42% matched.
Conclusions
- Sleeve lobectomy provides non-inferior short-term mortality compared to pneumonectomy.
- Sleeve lobectomy leads to superior long-term overall survival for centrally located NSCLC.
- Sleeve lobectomy should be the preferred surgical option when technically feasible.
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