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Updated: Jun 6, 2025

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
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[Hyperuricemia].

Ichiro Hisatome1

  • 1Yonago Medical Center.

No Shinkei Geka. Neurological Surgery
|December 2, 2024
PubMed
Summary
This summary is machine-generated.

High serum urate (SUA) levels cause gout and organ damage. Managing SUA levels and selecting appropriate urate-lowering agents based on specific hyperuricemia patterns is crucial for preventing disease.

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Area of Science:

  • Nephrology
  • Cardiology
  • Neurology

Background:

  • Hyperuricemia is linked to gout and significant organ damage, including cerebrovascular, cardiovascular, and lifestyle-related diseases.
  • The complex relationship between serum urate (SUA) levels and organ damage has been termed dysuricemia.

Purpose of the Study:

  • To redefine the relationship between SUA levels and various organ damages.
  • To emphasize the importance of maintaining optimal SUA levels for preventing organ damage.
  • To guide the selection of urate-lowering agents based on specific hyperuricemia patterns.

Main Methods:

  • Analysis of the association between SUA levels and gout occurrence (gout pattern).
  • Correlation analysis of SUA levels with neurodegenerative disease (ND pattern) occurrence.
  • Examination of the J-shaped curve relationship between SUA levels and chronic kidney disease (CKD)/cardiovascular disease (CVD) (CKD/CVD pattern).

Main Results:

  • SUA levels show a positive association with gout and intra-arterial gout.
  • A negative correlation exists between SUA levels and the occurrence of neurodegenerative diseases.
  • The relationship between SUA levels and CKD/CVD follows a J-shaped curve.

Conclusions:

  • Dysuricemia encompasses gout, ND, and CKD/CVD patterns, all associated with cardiovascular diseases.
  • Maintaining optimal SUA levels is essential for mitigating organ damage.
  • Tailoring urate-lowering agent selection (e.g., xanthine oxidase inhibitors for renal overload, uricosuric agents for renal undersecretion) to the specific hyperuricemia type is critical.