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Exploring Traits Associated With Central Sensitization Features in Patients With Chronic Cough
Haesung Jun1, Jin Young Park1, Ji-Yoon Oh2
1University of Ulsan College of Medicine, Seoul, Korea.
Allergy, Asthma & Immunology Research
|December 2, 2024
Summary
Central sensitization, indicated by high Central Sensitization Inventory (CSI) scores, is linked to specific traits in chronic cough patients. These findings highlight central sensitization
Area of Science:
- Pulmonology and Neuroscience
- Clinical Research on Chronic Cough
Background:
- Chronic cough is increasingly understood to involve cough hypersensitivity, suggesting central sensitization.
- The specific patient characteristics associated with central sensitization in chronic cough remain largely undefined.
Purpose of the Study:
- To investigate the traits associated with central sensitization features in patients diagnosed with chronic cough.
- To explore the correlation between central sensitization scores and various patient-reported outcomes in this cohort.
Main Methods:
- A cohort of 317 Korean patients with newly referred chronic cough was evaluated.
- Clinical assessments included the Central Sensitization Inventory (CSI) and other patient-reported outcomes (PROs) like the Leicester Cough Questionnaire (LCQ) and Cough Hypersensitivity Questionnaire (CHQ).
- Longitudinal follow-up was conducted after one month to assess the stability of findings.
Main Results:
- High CSI scores (≥ 40) were associated with female sex, older age, concomitant symptoms, and cough complications.
- CSI scores demonstrated significant correlations with cough-specific PROs (LCQ, CHQ) and depression-related scales (CES-D).
- These correlational patterns remained consistent in the longitudinal follow-up data.
Conclusions:
- Central sensitization, as measured by CSI scores, is relevant in specific chronic cough phenotypes.
- The association of CSI with cough-specific and depression-related outcomes suggests a complex interplay of factors in chronic cough.
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