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Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
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Causal relationship between strenuous exercise and muscle injury: a Mendelian randomization study with dual samples
Xin Huang1, Longxiang Huang2, Changhua Liu3
1College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China. 2328609454@qq.com.
European Journal of Applied Physiology
|December 2, 2024
Summary
Strenuous exercise increases the risk of lower limb muscle injuries, particularly in the hips and thighs. This study explored the physiological mechanisms behind exercise-induced muscle damage.
Area of Science:
- Exercise physiology
- Sports medicine
- Genetics
Background:
- Muscle injuries from strenuous exercise are a significant health concern for athletes.
- The physiological links between intense physical activity and muscle damage require further clarification.
Purpose of the Study:
- To systematically review the physiological mechanisms underlying the relationship between strenuous exercise and muscle injury incidence.
- To investigate the causal pathways contributing to exercise-induced muscle damage.
Main Methods:
- Systematic review utilizing Mendelian randomization with dual cohorts.
- Analysis of single-nucleotide polymorphisms (SNPs) associated with strenuous exercise.
- Inclusion of genome-wide association studies (GWAS) data for muscle injuries in hips, thighs, wrists, and hands.
- Comprehensive sensitivity analyses including inverse variance weighting and MR-Egger regression.
Main Results:
- A significant positive correlation was found between strenuous exercise and muscle injury risk in the hips and thighs (OR = 1.0046, p = 0.028).
- No significant causal link was identified between strenuous exercise and muscle injury in the wrist and hand muscles (OR = 0.9989, p = 0.834).
Conclusions:
- Strenuous exercise is positively associated with an increased risk of lower limb muscle injury.
- Physiological mechanisms contributing to muscle injury appear more pronounced in lower extremities than in upper limbs.
- Further research is needed to understand the differential susceptibility to injury in various muscle groups.
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