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Updated: Jun 6, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Task-Specific Design of a Porous Aromatic Framework as an Ultrastable Platform for Enantioselective Organocatalysis
Kun Liu1, Peng Chen1, Fan Chen1
1Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang, 315211, China.
Abstract:
A hydroxyl-tagged porous aromatic framework PAF-NBU2-OH was task-specifically designed and successfully synthesized targeted toward immobilizing chiral catalysts. Using proline-type compound as model chiral organocatalyst, PAF-NBU2-OH was used as a platform to covalently link proline-type group. The obtained PAF-immobilized organocatalyst PAF-NBU2-OPro featured high chemical stability in different solvents even under very harsh conditions. PAF-NBU2-OPro showed excellent catalytic activity, diastereoselectivity and enantioselectivity with complete and easy recyclability when catalyzing the aldol reaction between p-nitrobenzaldehyde and cyclohexanone, which could undergo at least 30 cycles without any activity, diastereoselectivity or enantioselectivity loss for catalyzing the current reaction.
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