Long term survival and outcomes in patients with paraneoplastic neurologic syndromes
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View abstract on PubMed
Summary
This summary is machine-generated.Delay in diagnosing paraneoplastic syndromes (PNS) did not impact mortality but significantly reduced quality of life. Early cancer detection is crucial for managing PNS and improving patient outcomes.
Area Of Science
- Neurology
- Oncology
- Immunology
Background
- Paraneoplastic syndromes (PNS) are rare neurological disorders triggered by cancer.
- The impact of diagnostic delay on PNS morbidity remains unclear.
- Understanding PNS characteristics is vital for timely diagnosis and management.
Purpose Of The Study
- To investigate the prevalence, clinical features, diagnostic criteria, and treatment outcomes of PNS.
- To explore the relationship between diagnostic delay and morbidity in PNS.
- To analyze survival rates and quality of life in patients with PNS.
Main Methods
- Retrospective study of 12 patients with positive onconeural antibodies, co-occurring cancer, and PNS phenotype (2016-2023).
- Analysis of clinical presentation, antibody profiles, cancer types, and treatment modalities.
- Evaluation of diagnostic timelines, functional outcomes (mRS), and survival data.
Main Results
- Common PNS antibodies included anti-GAD65, anti-Recoverin, and anti-Yo.
- Limbic encephalitis and encephalomyelitis were the most frequent phenotypes.
- Cancer preceded neurological symptoms in 6 cases; median time to cancer diagnosis was 73 days for those presenting with PNS.
- Immunotherapy (steroids, plasmapheresis) showed short-term benefit in 33% of patients.
- 9 out of 12 patients died, primarily due to cancer progression; 56% died younger than expected based on cancer type and stage.
Conclusions
- Diagnostic delay did not significantly affect mortality in PNS patients over 8 years.
- PNS significantly impairs quality of life, leading to long-term disability and functional impairment.
- Prompt diagnosis and integrated cancer-neurology care are essential for managing PNS.
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