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Right ventricular function and anemia in heart failure with preserved ejection fraction.
Jia Wang1, Jiahui Jiang2, Xiang Li2
1Emergency Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in Cardiovascular Medicine
|December 3, 2024
Summary
Anemia is linked to right ventricular (RV) dysfunction in Heart Failure with Preserved Ejection Fraction (HFpEF) patients. This association persists regardless of common risk factors like smoking and hypertension.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Anemia is a known complication in heart failure patients, often linked to left ventricular dysfunction.
- The specific impact of anemia on right ventricular (RV) function in Heart Failure with Preserved Ejection Fraction (HFpEF) remains under-explored.
Purpose of the Study:
- To investigate the relationship between anemia and RV dysfunction in HFpEF patients.
- To determine if classical risk factors influence the anemia-RV dysfunction association in HFpEF.
Main Methods:
- Retrospective analysis of electronic medical data from 1,014 HFpEF patients.
- Evaluation of anemia's correlation with RV function parameters, including tricuspid regurgitation (TR) and tricuspid annular plane systolic excursion (TAPSE)/pulmonary arterial systolic pressure (PASP) ratio.
- Multivariate regression analysis to identify independent predictors of RV dysfunction.
Main Results:
- Anemic HFpEF patients were older with higher NYHA functional class and TR.
- Hemoglobin levels correlated negatively with NT-pro-BNP and positively with the TAPSE/PASP ratio.
- Anemia, atrial fibrillation, and TR were independently associated with reduced RV function (TAPSE/PASP ratio).
Conclusions:
- Anemia is significantly associated with RV dysfunction in HFpEF.
- This relationship is independent of traditional risk factors such as smoking, hypertension, and diabetes.
Keywords:
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