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Evidence of the growth factor in mouse serum infected with Spirometra erinacei plerocercoids
Abstract:
To investigate the action of the growth factor secreted by Spirometra erinacei plerocercoids, various organ weights, body weight and head-body length were measured in Snell normal and dwarf mice after injection with the serum from mice and rats. Serum from mice infected with the plerocercoids caused significant increases in the weights of the liver and spleen, in the same manner as mice infected with the plerocercoids. However, serum from rats infected with plerocercoids did not cause significant changes in these parameters. The growth factor in the serum of mice infected with plerocercoids was stable at -20 degrees C for at least 6 months and easily passed through the peritoneum.
Insights
Serum from Spirometra erinacei-infected mice contains a stable growth factor that significantly increases liver and spleen weights in mice. This factor
Area of Science:
- Parasitology
- Molecular Biology
- Physiology
Background:
- Spirometra erinacei plerocercoids secrete factors that influence host physiology.
- Understanding these secreted factors is crucial for comprehending host-parasite interactions.
Purpose of the Study:
- To investigate the biological activity of the growth factor secreted by Spirometra erinacei plerocercoids.
- To determine the effects of serum containing this growth factor on host organ weights and body parameters.
Main Methods:
- Injection of serum from infected mice and rats into Snell normal and dwarf mice.
- Measurement of body weight, head-body length, and organ weights (liver, spleen).
- Assessment of growth factor stability at -20°C and its peritoneal permeability.
Main Results:
- Serum from mice infected with Spirometra erinacei plerocercoids significantly increased liver and spleen weights.
- Serum from rats infected with Spirometra erinacei plerocercoids did not yield significant changes in these parameters.
- The growth factor demonstrated stability at -20°C for over 6 months and was easily absorbed through the peritoneum.
Conclusions:
- A growth factor secreted by Spirometra erinacei plerocercoids in mice positively impacts host organ weights.
- This growth factor exhibits stability and bioavailability, suggesting potential for further research into its mechanisms and applications.
