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MicroRNAs and hypospadias: A systematic review
Mahboobeh Amoushahi1,2, Peter Hjorth Jørgensen2, Anastasia Buch Kjeldgaard1,2
1Laboratory of Tissue Engineering, Rigshospitalet, Faculty of Clinical Medicine, University of Copenhagen, 2100 Copenhagen, Denmark.
Medicine International
|December 3, 2024
Summary
MicroRNAs (miRNAs) play a role in hypospadias development. This systematic review highlights specific miRNAs involved in cell processes, suggesting their potential as diagnostic markers and therapeutic targets for hypospadias.
Area of Science:
- Developmental Biology
- Molecular Genetics
- Urology
Background:
- Hypospadias is a common congenital condition affecting the male urethra.
- The role of microRNAs (miRNAs) in hypospadias pathogenesis is not fully understood.
Purpose of the Study:
- To systematically review and summarize current knowledge on the involvement of miRNAs in hypospadias.
- To identify specific miRNAs and their regulatory functions in biological processes relevant to hypospadias.
Main Methods:
- Systematic literature review of MEDLINE (PubMed) and Embase databases.
- Search strategy using "hypospadias" AND "miRNA" terms, limited to English language articles.
- Inclusion criteria focused on original data, miRNA detection methods, and relevance to hypospadias.
Main Results:
- Seven specific miRNAs (miR-494, miR-145, miR-6756-5p, miR-182, miR-200c, miR-210, miR-1199-5p) were identified.
- These miRNAs were found to regulate critical cellular processes including wound healing, proliferation, growth, and apoptosis.
- miRNA extraction was performed from various biological samples like blood, penile tissues, and fibroblasts.
Conclusions:
- miRNAs are implicated as key regulatory molecules in hypospadias.
- These miRNAs show potential for development as biomarkers and therapeutic agents for hypospadias.
- Further research is warranted to explore the full potential of miRNAs in hypospadias.
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