Age- and Sex-Stratified Normogram Study of Corpus Callosum Dimensions in South Indian Individuals

Background The corpus callosum (CC) is an important structure of the brain consisting of various parts. The morphometric examination of physiological fluctuations in CC morphology is critical, as these variations may complicate the diagnosis and management of the individual. Therefore, it is important to assess and determine the range of such parameters. Materials and methods An observational, cross-sectional prospective hospital study was carried out over a period of one year, wherein 110 subjects attending our institution were assessed for the mean and range of different parts of the CC across equally distributed males and females, with the help of standardized parameters using MRI. Results The mean anteroposterior (AP) diameter of CC and the mean thickness of the genu, body, isthmus, and splenium were found to be 65.56±8.75 mm, 7.89±2.54 mm, 5.91±1.77 mm, 4.85±1.57 mm, and 8.57±1.92 mm, respectively. The AP diameter shows the greatest variability, with mean values increasing with age, whereas all other parameters such as the thickness of the genu, body, isthmus, and splenium were found to decrease with age. An assessment of these parameters between either gender revealed higher values among males in comparison to that of females, which was found to be statistically significant (p<0.05) across all parameters among the male and female genders. Conclusion The analysis of CC dimensions shows significant variability affected by age and gender. This study offers crucial baseline data on CC morphology, highlighting the important differences between males and females. Recognizing these normal anatomical variations can significantly improve clinical assessments of individuals with potential neurological issues. Further research is needed to investigate the clinical implications of these morphometric differences across different neurological contexts, which may lead to enhanced diagnostic and management approaches for affected individuals.