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Updated: Jun 6, 2025
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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ACE2, From the Kidney to SARS-CoV-2: Donald Seldin Award Lecture 2023
Daniel Batlle1, Luise Hassler1, Jan Wysocki1
1Division of Nephrology/Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Hypertension (Dallas, Tex. : 1979)
|December 3, 2024
Summary
Soluble angiotensin-converting enzyme 2 (ACE2) proteins offer dual therapeutic potential by targeting the kidney renin-angiotensin system and neutralizing SARS-CoV-2. Bioengineered soluble ACE2 provides protection against SARS-CoV-2 variants.
Area of Science:
- Biochemistry
- Molecular Biology
- Virology
Background:
- Angiotensin-converting enzyme 2 (ACE2) is a key enzyme metabolizing angiotensin II (Ang II) and acts as the cellular receptor for SARS-CoV-2.
- Membrane-bound ACE2 has renoprotective effects, while soluble ACE2 may offer therapeutic benefits.
- ACE2's dual role presents a unique therapeutic target for both cardiovascular and infectious diseases.
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