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Recruitment Strategies and Obstacles During the Zoster Eye Disease Study
Mark D Sherman1, Penny Asbell2, David Warner3
1Pacific Eye Surgeons, San Luis Obispo, CA.
Cornea
|December 3, 2024
Summary
Successful clinical trial recruitment relies on internal referrals and dedicated staff. Overcoming obstacles like travel and medication use is key for future studies, especially in reaching underserved populations.
Area of Science:
- Ophthalmology
- Clinical Trials
- Public Health
Background:
- The Zoster Eye Disease Study (ZEDS) aimed to understand recruitment dynamics.
- Principal investigators (PIs) reported various challenges and successes in enrolling participants.
Purpose of the Study:
- To identify effective recruitment strategies used in the Zoster Eye Disease Study (ZEDS).
- To determine common obstacles encountered by principal investigators (PIs) during ZEDS recruitment.
Main Methods:
- A web-based survey was distributed to ZEDS PIs after study closure.
- Survey data included objective measures and free-text responses on recruitment strategies and obstacles.
- Analysis compared high-enrollment centers with low-enrollment centers.
Main Results:
- Helpful strategies included internal ophthalmologist referrals (52%) and chart review (37%).
- Common obstacles were travel to clinical centers (67%) and prophylactic antiviral medication use (62%).
- Research coordinator turnover (49%) and limited outreach to minority populations (16%) were significant issues.
Conclusions:
- Internal referrals, chart review, and committed research staff are crucial for successful clinical trial recruitment.
- The impact of prophylactic antiviral medication on recruitment warrants further investigation.
- Future trials should adopt successful strategies and enhance outreach to underserved populations.
