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Published on: July 12, 2024
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Highly Water-Soluble Microneedle Patch for Short Wear Time and Rapid Drug Delivery
Amy J Wood-Yang1, Abishek Sankaranarayanan1, Max J Freidlin1
1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Molecular Pharmaceutics
|December 3, 2024
Summary
This study introduces rapidly dissolving microneedle (MN) patches for fast, easy drug delivery. The novel polyvinylpyrrolidone/lidocaine/sodium bicarbonate (PVP/L/NaB) MNs offer quick pain relief, improving on current methods.
Area of Science:
- Biomaterials Science
- Pharmaceutics
- Drug Delivery Systems
Background:
- Current local anesthetic delivery methods (topical, oral, injection) have limitations including slow onset, difficulty in administration, and need for expert handling.
- Microneedle (MN) patches offer a potential solution for painless, rapid drug delivery via skin penetration.
Purpose of the Study:
- To develop and evaluate a rapidly dissolving, highly water-soluble microneedle (MN) patch for accelerated local anesthetic delivery.
- To improve the speed and ease of drug administration for acute conditions requiring rapid pain relief.
Main Methods:
- Fabrication of microneedles (MNs) using polyvinylpyrrolidone (PVP) matrix loaded with lidocaine (L).
- Incorporation of sodium bicarbonate (NaB) to enhance MN dissolution rate.
- Ex vivo testing of MN dissolution time and lidocaine delivery in porcine skin.
Main Results:
- PVP/L/NaB MNs demonstrated a 60% faster dissolution rate in porcine skin compared to controls.
- The MNs achieved a lidocaine delivery of 23.8 ± 3.5 μg to the skin ex vivo.
- Wear time was minimized to approximately 10 seconds for rapid drug delivery.
Conclusions:
- The developed highly water-soluble PVP/L/NaB MN patch offers a significantly faster and easier alternative for drug delivery compared to traditional methods.
- This MN technology holds promise for rapid pain management and other applications requiring swift drug administration.
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