Elucidating epigenetic landscape of gastric premalignant lesions through genome-wide mapping of 5-hydroxymethylcytosines: A 12-year median follow-up study
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View abstract on PubMed
Summary
This summary is machine-generated.This study reveals the 5-hydroxymethylcytosines (5hmC) molecular landscape in gastric premalignant lesions. A novel 5hmC-based model shows promise in predicting gastric cancer progression risk.
Area Of Science
- Epigenetics and Cancer Biology
- Genomics and Molecular Pathology
- Gastroenterology and Oncology
Background
- Epigenetic modifications play a key role in cancer development.
- The role of 5-hydroxymethylcytosines (5hmC) in gastric premalignant lesion evolution is not well understood.
- Gastric adenocarcinoma (GAC) arises from a progression of premalignant lesions.
Purpose Of The Study
- To investigate the implications of 5hmC in the progression from gastric premalignant lesions to GAC.
- To explore the 5hmC molecular landscape in gastric premalignant lesions.
- To assess the feasibility of using 5hmC mapping for predicting cancer progression.
Main Methods
- Conducted a large-scale, longitudinal study of 29,176 Chinese patients with gastritis from 2001-2015.
- Performed genome-wide 5hmC mapping using the 5hmC-Seal assay on a subset of patients.
- Utilized multivariable logistic regression and machine learning to develop a predictive model.
Main Results
- Identified 213 differentially modified gene bodies linked to cell division, metabolism, inflammation, and tumorigenesis.
- Developed a nine-gene 5hmC-based model with an AUC of 87.5% for predicting cancer progression in validation samples.
- Found significant associations between 5hmC patterns and the evolution of gastric lesions.
Conclusions
- This is the first study to map the 5hmC landscape in gastric premalignant lesions.
- Identified key pathways involved in the progression to GAC.
- Demonstrated the potential of 5hmC mapping for assessing gastric cancer progression risk.
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