Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

2.9K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
2.9K
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

2.7K
Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
2.7K
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions01:20

Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions

1.8K
Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
1.8K
Preparation of Amides01:29

Preparation of Amides

3.0K
Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
3.0K
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview01:07

Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview

3.2K
In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
3.2K
Preparation of 1° Amines: Azide Synthesis01:22

Preparation of 1° Amines: Azide Synthesis

3.8K
Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research on exosomes in cancer multidrug resistance and clinical translation.

Extracellular vesicles and circulating nucleic acids·2026
Same author

A multidimensional landscape of extracellular vesicle-mediated tumor drug resistance: mechanisms, biomarkers, engineered drug delivery, and clinical translation.

Extracellular vesicles and circulating nucleic acids·2026
Same author

Dual targeting of interlocked PTK2B and MAPK signaling triggers synergistic ferroptosis via autophagic flux disruption in BRAF<sup>V600E</sup> glioma.

Cell communication and signaling : CCS·2026
Same author

Design, synthesis and insecticidal activities of novel meta-diamide compounds containing ethyl group.

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents·2026
Same author

Crystal structure and Hirshfeld surface analysis of saflufenacil.

Acta crystallographica. Section E, Crystallographic communications·2026
Same author

Corrigendum to "A pHe sensitive nanodrug for collaborative penetration and inhibition of metastatic tumors" [Journal of Controlled Release 352 (2022) 893-908].

Journal of controlled release : official journal of the Controlled Release Society·2026

Related Experiment Video

Updated: Jun 6, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
11:04

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

2.9K

Novel Meta-Diamide Derivatives Bearing Triazole: Design, Synthesis, and Bioactivity.

Chengyi Yan1, Jiyong Liu2, Juncheng Xiang2

  • 1School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, China.

Chemistry & Biodiversity
|December 3, 2024
PubMed
Summary

Researchers designed 20 novel meta-diamide compounds with triazole moieties. Compound 16a demonstrated potent insecticidal activity against Plutella xylostella and Mythimna separata, showing significant potential for pest control applications.

Keywords:
insecticidal activitiesmeta‐diamidestructure–activity relationshiptriazole

More Related Videos

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

9.7K
Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

6.6K

Related Experiment Videos

Last Updated: Jun 6, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
11:04

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

2.9K
Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

9.7K
Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

6.6K

Area of Science:

  • Agrochemical research
  • Organic synthesis
  • Insect toxicology

Background:

  • Development of novel insecticides is crucial for sustainable agriculture and pest management.
  • Meta-diamide compounds have shown promise as effective insecticidal agents.
  • Cyproflanilide serves as a lead compound for developing new insecticidal structures.

Purpose of the Study:

  • To design and synthesize novel meta-diamide compounds incorporating a triazole ring.
  • To evaluate the insecticidal efficacy of the synthesized compounds against key agricultural pests.
  • To investigate the structure-activity relationships (SAR) of these novel compounds.

Main Methods:

  • Synthesis of 20 new meta-diamide compounds containing triazole.
  • Characterization using Nuclear Magnetic Resonance (NMR) and High-resolution Mass Spectrometry (HR MS).
  • Preliminary bioassays to determine insecticidal activity against Plutella xylostella and Mythimna separata.

Main Results:

  • Compound 16a exhibited high insecticidal activity against Plutella xylostella (1 mg/L) and Mythimna separata (2 mg/L).
  • Compound 16a's efficacy was superior to known compounds Ia and Ib, and comparable to cyproflanilide.
  • The lethal concentration 50 (LC50) values for compound 16a were 0.90 mg/L for P. xylostella and 0.64 mg/L for M. separata.
  • Structure-activity relationship studies indicated that halogen substituents on the benzene ring and aromatic substituents on the amino group significantly impact insecticidal activity.

Conclusions:

  • Compound 16a represents a promising lead for the development of new insecticides.
  • The study provides valuable insights into the SAR of meta-diamide compounds, guiding future optimization.
  • Further structural modifications based on these findings could enhance insecticidal potency and spectrum.